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1

Trypanothione biosynthesis in Leishmania major

Sandra L. Oza, Matthew P. Shaw, Susan Wyllie, Alan H. Fairlamb

Journal:

Molecular and Biochemical Parasitology

Year:

2005

Language:

english

File:

PDF, 418 KB

english, 2005

2

Refinement of techniques for the propagation of Leishmania donovani in hamsters

Susan Wyllie, Alan H. Fairlamb

Journal:

Year:

2006

Language:

english

File:

PDF, 154 KB

english, 2006

3

Biochemistry of trypanosomiasis and rational approaches to chemotherapy

Journal:

Trends in Biochemical Sciences

Year:

1982

Language:

english

File:

PDF, 554 KB

english, 1982

4

Target Validation: Linking Target and Chemical Properties to Desired Product Profile

G. Wyatt, Paul, H. Gilbert, Ian, D. Read, Kevin, H. Fairlamb, Alan

Journal:

Current Topics in Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 149 KB

english, 2011

5

Metabolic Pathway Analysis in Trypanosomes and Malaria Parasites

Alan H. Fairlamb

Journal:

Philosophical Transactions Biological Sciences

Year:

2002

Language:

english

File:

PDF, 1.19 MB

english, 2002

6

ChemInform Abstract: Synthesis and Evaluation of 9,9-Dimethylxanthene Tricyclics Against Trypanothione Reductase, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani.

Kelly Chibale, Mark Visser, Vanessa Yardley, Simon L. Croft, Alan H. Fairlamb

Journal:

Year:

2000

File:

PDF, 28 KB

2000

7

ChemInform Abstract: Antiprotozoal and Cytotoxicity Evaluation of Sulfonamide and Urea Analogues of Quinacrine.

Kelly Chibale, Hayley Haupt, Howard Kendrick, Vanessa Yardley, Ahilan Saravanamuthu, Alan H. Fairlamb, Simon L. Croft

Journal:

Year:

2002

File:

PDF, 30 KB

2002

8

ChemInform Abstract: Regiocontrolled Synthesis of the Macrocyclic Polyamine Alkaloid (.+-.)-Lunarine, a Time-Dependent Inhibitor of Trypanothione Reductase.

Chris J. Hamilton, Alan H. Fairlamb, Ian M. Eggleston

Journal:

Year:

2002

File:

PDF, 27 KB

2002

9

Cycloisomerization of Modified Terpenoid 1,6-Enynes — Synthesis of Conformationally-Restricted Cyclic Farnesyl Analogues.

Ian J. S. Fairlamb, Alan C. Pike, Sebastien P. C. P. Ribrioux

Journal:

Year:

2002

File:

PDF, 29 KB

2002

10

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase

Stephen Patterson, Deuan C. Jones, Emma J. Shanks, Julie A. Frearson, Ian H. Gilbert, Paul G. Wyatt, Alan H. Fairlamb

Journal:

Year:

2009

Language:

english

File:

PDF, 403 KB

english, 2009

11

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis

John L. Richardson, Isabelle R. E. Nett, Deuan C. Jones, Mohamed H. Abdille, Ian H. Gilbert, Alan H. Fairlamb

Journal:

Year:

2009

Language:

english

File:

PDF, 387 KB

english, 2009

12

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Daniel Spinks, Emma J. Shanks, Laura A. T. Cleghorn, Stuart McElroy, Deuan Jones, Daniel James, Alan H. Fairlamb, Julie A. Frearson, Paul G. Wyatt, Ian H. Gilbert

Journal:

Year:

2009

Language:

english

File:

PDF, 366 KB

english, 2009

13

Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)

John L. Richardson, Isabelle R. E. Nett, Deuan C. Jones, Mohamed H. Abdille, Ian H. Gilbert, Alan H. Fairlamb, Stephen Patterson, Deuan C. Jones, Emma J. Shanks, Julie A. Frearson, Paul G. Wyatt

Journal:

Year:

2009

Language:

english

File:

PDF, 1.00 MB

english, 2009

14

Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase

Dr. Jeffrey G. A. Walton, Dr. Deuan C. Jones, Dr. Paula Kiuru, Dr. Alastair J. Durie, Dr. Nicholas J. Westwood, Prof. Alan H. Fairlamb

Journal:

Year:

2011

Language:

english

File:

PDF, 263 KB

english, 2011

15

Optimisation of the Anti-Trypanosoma brucei Activity of the Opioid Agonist U50488

Victoria C. Smith, Dr. Laura A. T. Cleghorn, Dr. Andrew Woodland, Daniel Spinks, Irene Hallyburton, Iain T. Collie, Dr. N. Yi Mok, Suzanne Norval, Dr. Ruth Brenk, Prof. Alan H. Fairlamb, Prof. Julie A

Journal:

Year:

2011

Language:

english

File:

PDF, 291 KB

english, 2011

16

Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors

Daniel Spinks, Dr. Leah S. Torrie, Dr. Stephen Thompson, Dr. Justin R. Harrison, Prof. Julie A. Frearson, Dr. Kevin D. Read, Prof. Alan H. Fairlamb, Prof. Paul G. Wyatt, Prof. Ian H. Gilbert

Journal:

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

17

Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)

Dr. Jeffrey G. A. Walton, Dr. Deuan C. Jones, Dr. Paula Kiuru, Dr. Alastair J. Durie, Dr. Nicholas J. Westwood, Prof. Alan H. Fairlamb, Daniel Spinks, Dr. Han B. Ong, Dr. Chidochangu P. Mpamhanga, Dr.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

18

Separation and quantitation of the polyamine biosynthesis inhibitor d,l-α-difluoromethylarginine and other guanidine-containing compounds by high-performance liquid chromatography

Karl J. Hunter, Alan H. Fairlamb

Journal:

Analytical Biochemistry

Year:

1990

Language:

english

File:

PDF, 474 KB

english, 1990

19

High-performance liquid chromatographic method for the separation and quantitative estimation of anti-parasitic melaminophenyl arsenical compounds

Bradley J. Berger, Alan H. Fairlamb

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

1994

Language:

english

File:

PDF, 389 KB

english, 1994

20

Time-dependent inhibitors of trypanothione reductase: Analogues of the spermidine alkaloid lunarine and related natural products

Chris J. Hamilton, Ahilan Saravanamuthu, Christiane Poupat, Alan H. Fairlamb, Ian M. Eggleston

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 259 KB

english, 2006

21

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

Emma J. Shanks, Han B. Ong, David A. Robinson, Stephen Thompson, Natasha Sienkiewicz, Alan H. Fairlamb, Julie A. Frearson

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 948 KB

english, 2010

22

Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents

Kelly Chibale, Mark Visser, Donelly van Schalkwyk, Peter J Smith, Ahilan Saravanamuthu, Alan H Fairlamb

Journal:

Year:

2003

Language:

english

File:

PDF, 235 KB

english, 2003

23

Cycloisomerisation of modified terpenoid 1,6-enynes—synthesis of conformationally-restricted cyclic farnesyl analogues

Ian J.S. Fairlamb, Alan C. Pike, Sebastien P.C.P. Ribrioux

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

24

Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani

Kelly Chibale, Mark Visser, Vanessa Yardley, Simon L. Croft, Alan H. Fairlamb

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

25

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine

Kelly Chibale, Hayley Haupt, Howard Kendrick, Vanessa Yardley, Ahilan Saravanamuthu, Alan H Fairlamb, Simon L Croft

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 91 KB

english, 2001

26

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group

Katie Amssoms, Sandra L Oza, Esteban Ravaschino, Abdellah Yamani, Anne-Marie Lambeir, Padinchare Rajan, Gunther Bal, Juan Bautista Rodriguez, Alan H Fairlamb, Koen Augustyns, Achiel Haemers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

27

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

Ching-Kim Tye, Ganasan Kasinathan, Michael P. Barrett, Reto Brun, Valerie E. Doyle, Alan H. Fairlamb, Richard Weaver, Ian H. Gilbert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 308 KB

english, 1998

28

Benzofuranyl 3,5-bis-Polyamine derivatives as time-Dependent inhibitors of trypanothione reductase

Chris J. Hamilton, Ahilan Saravanamuthu, Alan H. Fairlamb, Ian M. Eggleston

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 333 KB

english, 2003

29

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

Jorge Tovar, Shane Wilkinson, Jeremy C. Mottram, Alan H. Fairlamb

Journal:

Molecular Microbiology

Year:

1998

Language:

english

File:

PDF, 405 KB

english, 1998

30

The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution

Yihong Zhang, Charles S. Bond, Susan Bailey, Mark L. Cunningham, Alan H. Fairlamb, William N. Hunter

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 10.72 MB

english, 1996

31

Synthesis of N-benzyloxycarbonyl-l-cysteinylglycine 3-dimethylaminopropylamide disulfide: A cheap and convenient new assay for trypanothione reductase

Abdussalam El-Waer, Kenneth T. Douglas, Keith Smith, Alan H. Fairlamb

Journal:

Analytical Biochemistry

Year:

1991

Language:

english

File:

PDF, 552 KB

english, 1991

32

Future prospects for the chemotherapy of human trypanosomiasis: 1. Novel approaches to the chemotherapy of trypanosomiasis

Alan H. Fairlamb

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

1990

Language:

english

File:

PDF, 611 KB

english, 1990

33

Phosphonic acid and phosphinic acid tripeptides as inhibitors of glutathionylspermidine synthetase

Christophe Verbruggen, Sofie De Craecker, Padinchare Rajan, Xian-Yun Jiao, Marianne Borloo, Keith Smith, Alan H. Fairlamb, Achiel Haemers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 269 KB

english, 1996

34

Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening

Georgina A. Holloway, Jonathan B. Baell, Alan H. Fairlamb, Patrizia M. Novello, John P. Parisot, John Richardson, Keith G. Watson, Ian P. Street

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 202 KB

english, 2007

35

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity

Derek C. Martyn, Deuan C. Jones, Alan H. Fairlamb, Jon Clardy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

36

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: Substitution of the glycine part

Katie Amssoms, Sandra L Oza, Koen Augustyns, Abdellah Yamani, Anne-Marie Lambeir, Gunther Bal, Pieter Van der Veken, Alan H Fairlamb, Achiel Haemers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

37

Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiophen-4,9-quinones

Carlos L. Zani, Egler Chiari, Antoniana U. Krettli, Silvane M.F. Murta, Mark L. Cunningham, Alan H. Fairlamb, Alvaro J. Romanha

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 743 KB

english, 1997

38

Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme

Antonio Ariza, Tim J. Vickers, Neil Greig, Kirsten A. Armour, Mark J. Dixon, Ian M. Eggleston, Alan H. Fairlamb, Charles S. Bond

Journal:

Molecular Microbiology

Year:

2006

Language:

english

File:

PDF, 4.62 MB

english, 2006

39

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

Alice Dawson, Federica Gibellini, Natasha Sienkiewicz, Lindsay B. Tulloch, Paul K. Fyfe, Karen McLuskey, Alan H. Fairlamb, William N. Hunter

Journal:

Molecular Microbiology

Year:

2006

Language:

english

File:

PDF, 864 KB

english, 2006

40

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes

Natasha Sienkiewicz, Szymon Jarosławski, Susan Wyllie, Alan H. Fairlamb

Journal:

Molecular Microbiology

Year:

2008

Language:

english

File:

PDF, 665 KB

english, 2008

41

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods

Susan Wyllie, Sandra L. Oza, Stephen Patterson, Daniel Spinks, Stephen Thompson, Alan H. Fairlamb

Journal:

Molecular Microbiology

Year:

2009

Language:

english

File:

PDF, 287 KB

english, 2009

42

Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

Natasha Sienkiewicz, Han B. Ong, Alan H. Fairlamb

Journal:

Molecular Microbiology

Year:

2010

Language:

english

File:

PDF, 1.26 MB

english, 2010

43

A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major

Janine König, Alan H. Fairlamb

Journal:

Year:

2007

Language:

english

File:

PDF, 2.09 MB

english, 2007

44

ATP-dependent ligases in trypanothione biosynthesis – kinetics of catalysis and inhibition by phosphinic acid pseudopeptides

Sandra L. Oza, Shoujun Chen, Susan Wyllie, James K. Coward, Alan H. Fairlamb

Journal:

Year:

2008

Language:

english

File:

PDF, 743 KB

english, 2008

45

A comparative study of methylglyoxal metabolism in trypanosomatids

Neil Greig, Susan Wyllie, Stephen Patterson, Alan H. Fairlamb

Journal:

Year:

2009

Language:

english

File:

PDF, 349 KB

english, 2009

46

New approach to screening drugs for activity against African trypanosomes

FAIRLAMB, ALAN H., OPPERDOES, FRED R., BORST, PIET

Journal:

Year:

1977

File:

PDF, 219 KB

1977

47

Arsenical-resistant trypanosomes lack an unusual adenosine transporter

Carter, Nicola S., Fairlamb, Alan H.

Journal:

Year:

1993

File:

PDF, 476 KB

1993

48

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

Aliberti, Julio, Valenzuela, Jesus G., Carruthers, Vern B., Hieny, Sara, Andersen, John, Charest, Hugues, e Sousa, Caetano Reis, Fairlamb, Alan, Ribeiro, Jose M., Sher, Alan

Journal:

Nature Immunology

Year:

2003

Language:

english

File:

PDF, 1.06 MB

english, 2003

49

Triclosan is minimally effective in rodent malaria models

Baschong, Werner, Wittlin, Sergio, Inglis, Kirstine A, Fairlamb, Alan H, Croft, Simon L, Kumar, T R Santha, Fidock, David A, Brun, Reto

Journal:

Nature Medicine

Year:

2011

Language:

english

File:

PDF, 123 KB

english, 2011

50

A simple magnetic method for the purification of malarial pigment

Alan H. Fairlamb, Frank Paul, David C. Warhurst

Journal:

Molecular and Biochemical Parasitology

Year:

1984

Language:

english

File:

PDF, 296 KB

english, 1984

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